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Overexpression of DNA Methyltransferases 1, 3a, and 3b Significantly Correlates With Retinoblastoma Tumorigenesis

20 Oct 2010

Abstract excerpt

DNA methyltransferases (DNMTs) 1, 3a, and 3b affect DNA promoter methylation; studies have suggested that they have important roles in the development of cancers. In this study, we analyzed the expression of DNMTs 1, 3a, and 3b; the MIB-1 labeling index; and their clinical significance in 6 normal retinas and 62 retinoblastomas using immunohistochemical analysis. We found that DNMT proteins were not expressed in...

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PMID: 20959668
DOI: 10.1309/ajcphgq69fxdfwii

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