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Article

Deoxyribonucleic Acid Methyltransferase 3B Promotes Epigenetic Silencing through Histone 3 Chromatin Modifications in Pituitary Cells

11 Jun 2008

Abstract excerpt

CONTEXT AND OBJECTIVE: Epigenetic dysregulation is implicated in pituitary neoplasia as the cause of silencing of several tumor suppressor genes. However, the upstream mediators of such events remain unknown. DESIGN: We examined the three members of the DNA methyltransferase (DNMT) enzyme family in normal and neoplastic human and mouse pituitary cells. SETTING: This study was performed at a university-affiliated...

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PMID: 18544619
DOI: 10.1210/jc.2008-0578

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