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Article

SHP-2 Activating Mutation Promotes Malignant Biological Behaviors of Glioma Cells.

Medical science monitor : international medical journal of experimental and clinical research - 16 Jun 2017

Zhao Yong, Lin Lin, Zhang Yonghui, Geng Dangmurenjiafu

Abstract excerpt

BACKGROUND This study investigated the mechanism underlying the activating mutation of SHP-2 in promoting malignant biological behaviors of glioma cells. MATERIAL AND METHODS The SHP-2 empty plasmid pcDNA3.1 and SHP-2 activating mutation plasmid pcDNA3.1 SHP-2 D61G mutant eukaryotic expression vectors were designed; stable SHP-2-expressing cells transfected with pcDNA3.1 SHP-2 D61G mutant were set as the mutation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28620155
DOI: 10.12659/msm.904381
PMCID: PMC5484608

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