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Arabidopsis Fhit-like tumor suppressor resumes early terminated constitutive triple response1-10 mRNA translation.

Plant physiology - 28 Jun 2024

Zhang Ranran, Zhang Wei, Wang Chenrunshu, Wen Chi-Kuang

Abstract excerpt

The Arabidopsis (Arabidopsis thaliana) constitutive triple response1-10 (ctr1-10) mutant produces a reduced level of CTR1 protein and exhibits a weak ctr1 mutant phenotype. Sequence analysis revealed highly active translation of the upstream open reading frame (uORF) at the extended 5'-UTR of the ctr1-10 mRNA, resulting from T-DNA insertion. Enhancer screening for ctr1-10 isolated the fragile histidine triad-1...

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PMID: 38563472
DOI: 10.1093/plphys/kiae192

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