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Genetic polymorphism in UDP-glucuronosyltransferase 2B7 and colorectal cancer risk.

Oncology research - 1 Jan 2009

van der Logt E M J, te Morsche R H M, Groenendaal N, Roelofs H M J, de Metz M, van der Stappen J W, Nagengast F M, Peters W H M

Abstract excerpt

Colorectal cancer (CRC) is one of the most common malignancies in the Western world. CRC is strongly associated with lifestyle factors. Susceptibility to CRC may be partly due to deficient detoxification capacity in the gastrointestinal tract. Genetic polymorphisms in detoxification enzymes result in variations in detoxification activities, which might influence the levels of carcinogens in the gastrointestinal...

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PMID: 19408577
DOI: 10.3727/096504009787721203

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