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Article

UGT1A1 and UGT1A9 functional variants, meat intake, and colon cancer, among Caucasians and African-Americans.

Mutation research - 26 Sept 2008

Girard Hugo, Butler Lesley M, Villeneuve Lyne, Millikan Robert C, Sinha Rashmi, Sandler Robert S, Guillemette Chantal

Abstract excerpt

Glucuronidation by the UDP-glucuronosyltransferase enzymes (UGTs) is one of the primary detoxification pathways of dietary heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs). In a population-based case-control study of 537 cases and 866 controls, we investigated whether colon cancer was associated with genetic variations in UGT1A1 and UGT1A9 genes and we determined if those variations modify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18675828
DOI: 10.1016/j.mrfmmm.2008.07.002
PMCID: PMC2570038

Genes

PAH

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