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Article

Quantitative trait mapping in Diversity Outbred mice identifies two genomic regions associated with heart size.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2018

Shorter John R, Huang Wei, Beak Ju Youn, Hua Kunjie, Gatti Daniel M, de Villena Fernando Pardo-Manuel, Pomp Daniel, Jensen Brian C

Abstract excerpt

Heart size is an important factor in cardiac health and disease. In particular, increased heart weight is predictive of adverse cardiovascular outcomes in multiple large community-based studies. We use two cohorts of Diversity Outbred (DO) mice to investigate the role of genetics, sex, age, and diet on heart size. DO mice (n = 289) of both sexes from generation 10 were fed a standard chow diet, and analyzed at...

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Source

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Identifiers

PMID: 29279960
DOI: 10.1007/s00335-017-9730-7
PMCID: PMC6340297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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