Article
Age and diet shape the genetic architecture of body weight in diversity outbred mice.
eLife - 15 Jul 2022
Wright Kevin M, Deighan Andrew G, Di Francesco Andrea, Freund Adam, Jojic Vladimir, Churchill Gary A, Raj Anil
Abstract excerpt
Understanding how genetic variation shapes a complex trait relies on accurately quantifying both the additive genetic and genotype-environment interaction effects in an age-dependent manner. We used a linear mixed model to quantify diet-dependent genetic contributions to body weight measured through adulthood in diversity outbred female mice under five diets. We observed that heritability of body weight declined...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.