Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ANLN Plays a Critical Role in Human Lung Carcinogenesis through the Activation of RHOA and by Involvement in the Phosphoinositide 3-Kinase/AKT Pathway

15 Dec 2005

Abstract excerpt

Gene expression profile analysis of non-small cell lung cancers (NSCLC) and subsequent functional analyses revealed that human ANLN, a homologue of anillin, an actin-binding protein in Drosophila, was transactivated in lung cancer cells and seemed to play a significant role in pulmonary carcinogenesis. Induction of small interfering RNAs against ANLN in NSCLC cells suppressed its expression and resulted in growth...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Protein Kinase Regulation and GTPase Signaling
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16357138
DOI: 10.1158/0008-5472.can-05-1507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ANLN Plays a Critical Role in Human Lung Carcinogenesis through the Activation of RHOA and by Involvement in the Phosphoinositide 3-Kinase/AKT PathwayPMID 16357138Read ↗

Prognostic significance of ANLN in lung adenocarcinomaSemantic proximity Read ↗

ANLN and Lung Adenocarcinoma Prognosis and Immune Infiltration ResearchSemantic proximity Read ↗

Comprehensive analyses reveal the carcinogenic and immunological roles of ANLN in human cancersSemantic proximity Read ↗

ANLN, Regulated by SP2, Promotes Colorectal Carcinoma Cell Proliferation via PI3K/AKT and MAPK Signaling PathwaySemantic proximity Read ↗

Knockdown of ANLN inhibits the progression of lung adenocarcinoma via pyroptosis activationSemantic proximity Read ↗

Comprehensive Analysis of ANLN in Human Tumors: A Prognostic Biomarker Associated with Cancer ImmunitySemantic proximity Read ↗

ANLN promotes carcinogenesis in oral cancer by regulating PI3K/mTOR signaling pathwaySemantic proximity Read ↗

Neuregulin1 acts as a suppressor in human lung adenocarcinoma via AKT and ERK1/2 pathwaySemantic proximity Read ↗

Actin‐like protein 8 promotes cell proliferation, colony‐formation, proangiogenesis, migration and invasion in lung adenocarcinoma cellsSemantic proximity Read ↗

Overexpression of Nemo-like Kinase Promotes the Proliferation and Invasion of Lung Cancer Cells and Indicates Poor PrognosisSemantic proximity Read ↗

Long noncoding RNA ANRIL could be transactivated by c-Myc and promote tumor progression of non-small-cell lung cancerSemantic proximity Read ↗

Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.