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Article

Synergism between apolipoprotein E Ɛ4 allele and paraoxonase (PON1) 55-M allele is associated with risk of systemic lupus erythematosus.

Clinical rheumatology - 1 Apr 2018

Tanhapour Maryam, Miri Ali, Vaisi-Raygani Asad, Bahrehmand Fariborz, Kiani Amir, Rahimi Zohreh, Pourmotabbed Tayebeh, Shakiba Ebrahim

Abstract excerpt

Evidences indicate that abnormal lipid metabolism and lipid peroxidation can affect the progression of complications in systemic lupus erythematosus (SLE) patients. Apolipoprotein E (ApoE) and paraoxonase-1 (PON1) play important role in lipid metabolism and protection of lipid peroxidation. The polymorphisms of ApoE and paraoxonase (PON1) L55M (Met < Leu) allele genes lead to disorders in lipid metabolism and are...

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Identifiers

PMID: 29273831
DOI: 10.1007/s10067-017-3859-3

Genes

PON1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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