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In‐depth comparison of N‐glycosylation of human plasma‐derived factor VIII and different recombinant products: from structure to clinical implications

11 Jun 2018

Abstract excerpt

Unlabelled Box •Glycosylation heterogeneity of recombinant proteins affects pharmacokinetics and immunogenicity. •N‐glycomics/glycoproteomics of plasma‐derived Factor VIII and 6 recombinant FVIIIs were compared. •Depending on cell line, significant differences to plasma‐derived FVIII were observed. •Recombinant FVIIIs expressed distinct and immunologically relevant epitopes. Summary: Background/Objective Human...

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PMID: 29888865
DOI: 10.1111/jth.14204

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