Article
Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity.
The Journal of biological chemistry - 9 Feb 2018
Wu Jheng-Yu, Xiang Shengyan, Zhang Mu, Fang Bin, Huang He, Kwon Oh Kwang, Zhao Yingming, Yang Zhe, Bai Wenlong, Bepler Gerold, Zhang Xiaohong Mary
Abstract excerpt
Histone deacetylase 6 (HDAC6), a class IIb HDAC, plays an important role in many biological and pathological processes. Previously, we found that ERK1, a downstream kinase in the mitogen-activated protein kinase signaling pathway, phosphorylates HDAC6, thereby increasing HDAC6-mediated deacetylation of α-tubulin. However, whether HDAC6 reciprocally modulates ERK1 activity is unknown. Here, we report that both...
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