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Article

Whole-exome sequencing demonstrates recurrent somatic copy number alterations and sporadic mutations in specialized stromal tumors of the prostate.

Human pathology - 1 Jun 2018

Pan Chin-Chen, Tsuzuki Toyonori, Morii Eiichi, Fushimi Hiroaki, Chen Paul Chih-Hsueh, Epstein Jonathan I

Abstract excerpt

In a previous array comparative genomic hybridization study, we detected common deletions of chromosomes 13 and 14 in prostatic stromal sarcoma and stromal tumor of uncertain malignant potential (STUMP). In this study, we performed whole-exome sequencing (WES) and fluorescence in situ hybridization to explore somatic mutations in 1 low-grade stromal sarcoma, 1 high-grade stromal sarcoma, and 12 STUMPs including 5...

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PMID: 29258903
DOI: 10.1016/j.humpath.2017.12.004

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