Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recurrent copy number alterations in low-grade and anaplastic pleomorphic xanthoastrocytoma with and without BRAF V600E mutation.

Brain pathology (Zurich, Switzerland) - 1 Mar 2018

Vaubel Rachael A, Caron Alissa A, Yamada Seiji, Decker Paul A, Eckel Passow Jeanette E, Rodriguez Fausto J, Nageswara Rao Amulya A, Lachance Daniel, Parney Ian, Jenkins Robert, Giannini Caterina

Abstract excerpt

Pleomorphic xanthoastrocytoma (PXA) is a rare localized glioma characterized by frequent BRAF V600E mutation and CDKN2A/B deletion. We explored the association of copy-number variants (CNVs) with BRAF mutations, tumor grade, and patient survival in a cohort of 41 PXA patients using OncoScan chromosomal microarray. Primary resection specimens were available in 38 cases, including 24 PXA and 14 anaplastic PXA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebellar Neoplasms
Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p15

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Cyclin-Dependent Kinase Inhibitor p18

Share to Glioma

Share to Neoplasm Recurrence, Local

Share to SMARCB1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 28181325
DOI: 10.1111/bpa.12495
PMCID: PMC5807227

Genes

BRAF
CDKN2A
SMARCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recurrent copy number alterations in low-grade and anaplastic pleomorphic xanthoastrocytoma with and without BRAF V600E mutation.PMID 28181325Read ↗

Genomic Alteration Patterns Across Histological Grades in BRAF p.V600E-Mutant Gliomas and Glioneuronal Tumors: An Analysis of 15 Cases.Semantic proximity Read ↗

Biology and grading of pleomorphic xanthoastrocytoma—what have we learned about it?Semantic proximity Read ↗

The genetic landscape of anaplastic pleomorphic xanthoastrocytoma.Semantic proximity Read ↗

BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications.Semantic proximity Read ↗

Molecular, histologic, and clinical characterization of methylation class pleomorphic xanthoastrocytoma: An analysis of 469 tumorsSemantic proximity Read ↗

A novel, potentially targetable TMEM106B-BRAF fusion in pleomorphic xanthoastrocytoma.Semantic proximity Read ↗

Pleomorphic xanthoastrocytoma is a heterogeneous entity with pTERT mutations prognosticating shorter survival.Semantic proximity Read ↗

The evolution of pleomorphic xanthoastrocytoma: from genesis to molecular alterations and mimics.Semantic proximity Read ↗

Genetic alterations commonly found in diffusely infiltrating cerebral gliomas are rare or absent in pleomorphic xanthoastrocytomas.Semantic proximity Read ↗

Comparing loss of p16 and MTAP expression in detecting CDKN2A homozygous deletion in pleomorphic xanthoastrocytomaSemantic proximity Read ↗

Impact of Grade on Survival in Pleomorphic Xanthoastrocytoma and Low Prevalence of BRAF V600E Mutation.Semantic proximity Read ↗

Epithelioid Glioblastoma or Anaplastic Pleomorphic Xanthoastrocytoma? Lessons from A Rare High Grade Neuroepithelial Tumor with a Novel Germline FANCA MutationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.