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Article

COQ2 polymorphisms are not associated with increased risk of statin-induced myalgia/myopathy in the Czech population.

Drug metabolism and personalized therapy - 20 Dec 2017

Hubacek Jaroslav A, Adamkova Vera, Zlatohlavek Lukas, Steiner-Mrazova Lenka, Vrablik Michal

Abstract excerpt

BACKGROUND: The gene COQ2, encoding 4-hydroxybenzoate-polyprenyltransferase (coenzyme Q2), belongs to the candidates potentially influencing statin treatment tolerability. This enzyme is involved in the biosynthesis of coenzyme Q10 (CoQ10), in which depletion induced by statin treatment is implicated in the development of statin-associated muscle symptoms (SAMS). Thus, polymorphisms in the COQ2 gene might explain...

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Identifiers

PMID: 29257754
DOI: 10.1515/dmpt-2017-0027

Genes

COQ2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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