Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of H3F3A p.G35W and p.G35R in giant cell tumor of bone by Allele Specific Locked Nucleic Acid quantitative PCR (ASLNAqPCR).

Pathology, research and practice - 1 Jan 2018

Gamberi Gabriella, Morandi Luca, Benini Stefania, Resca Anna, Cocchi Stefania, Magagnoli Giovanna, Donati Davide Maria, Righi Alberto, Gambarotti Marco

Abstract excerpt

Giant Cell Tumor (GCT) represents about 20% of benign bone tumors, is locally aggressive although malignant transformation is extremely rare, <1% of cases but 2-3% give pulmonary metastasis. Age at onset is between 20 and 40 years with a slight predominance for the female gender. GCT is characterized by specific mutations in H3F3A gene encoding the protein histone 3.3. The study of these mutations is important...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Bone Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diagnosis, Differential

Share to DNA Mutational Analysis

Share to Histones

Share to Lung Neoplasms

Share to Predictive Value of Tests

Share to Real-Time Polymerase Chain Reaction

Source

Identifiers

PMID: 29254795
DOI: 10.1016/j.prp.2017.10.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of H3F3A p.G35W and p.G35R in giant cell tumor of bone by Allele Specific Locked Nucleic Acid quantitative PCR (ASLNAqPCR).PMID 29254795Read ↗

H3-3A gene mutation analysis in giant cell tumor of bone and its histologic mimics: A single institutional study from India.Semantic proximity Read ↗

H3F3A mutation as a marker of malignant giant cell tumor of the bone: A case report and review of literature.Semantic proximity Read ↗

Histone H3.3 mutation in giant cell tumor of bone: an update in pathology.Semantic proximity Read ↗

Diagnostic value of H3F3A mutations in giant cell tumour of bone compared to osteoclast‐rich mimicsSemantic proximity Read ↗

Histone 3.3 mutations in giant cell tumor and giant cell-rich sarcomas of bone.Semantic proximity Read ↗

H3F3A G34 mutation DNA sequencing and G34W immunohistochemistry analysis in 366 cases of giant cell tumors of bone and other bone tumors.Semantic proximity Read ↗

Giant cell tumor of bone with H3F3B mutation: A case report.Semantic proximity Read ↗

H3F3A mutation in giant cell tumour of the bone is detected by immunohistochemistry using a monoclonal antibody against the G34W mutated site of the histone H3.3 variant.Semantic proximity Read ↗

Mutation Analysis of H3F3A and H3F3B as a Diagnostic Tool for Giant Cell Tumor of Bone and Chondroblastoma.Semantic proximity Read ↗

H3F3A-mutated giant cell tumour of bone without giant cells-clinical presentation, radiology and histology of three cases.Semantic proximity Read ↗

Highly recurrent H3F3A mutations with additional epigenetic regulator alterations in giant cell tumor of boneSemantic proximity Read ↗

Diagnostic utility of histone H3.3 G34W, G34R, and G34V mutant-specific antibodies for giant cell tumors of bone.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.