Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mendelian randomization study shows no causal relationship between circulating urate levels and Parkinson's disease.

Annals of neurology - 1 Aug 2018

Kia Demis A, Noyce Alastair J, White Jon, Speed Doug, Nicolas Aude, Burgess Stephen, Lawlor Debbie A, Davey Smith George, Singleton Andrew, Nalls Mike A, Sofat Reecha, Wood Nicholas W

Abstract excerpt

OBJECTIVE: Observational studies have shown that increased plasma urate is associated with lower risk of Parkinson's disease (PD), but these studies were not designed to test causality. If a causal relationship exists, then modulating plasma urate levels could be a potential preventive avenue for PD. We used a large two-sample Mendelian randomization (MR) design to assess for a causal relationship between plasma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Databases, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Gout, Hyperuricemia, Uric Acid

Share to Mendelian Randomization Analysis

Share to Parkinson Disease

Share to Polymorphism, Single Nucleotide

Share to Uric Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 30014513
DOI: 10.1002/ana.25294
PMCID: PMC6481555

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mendelian randomization study shows no causal relationship between circulating urate levels and Parkinson's disease.PMID 30014513Read ↗

No causal relationship between serum urate and neurodegenerative diseases: A Mendelian randomization study.Semantic proximity Read ↗

Plasma urate and risk of Parkinson's disease: A mendelian randomization study.Semantic proximity Read ↗

Mendelian Randomisation Finds No Causal Association between Urate and Parkinson's Disease ProgressionSemantic proximity Read ↗

No association between genetically predicted vitamin D levels and Parkinson's disease.Semantic proximity Read ↗

Systematic genome-wide Mendelian randomization reveals the causal links between miRNAs and Parkinson’s diseaseSemantic proximity Read ↗

Serum Calcium Levels and Parkinson’s Disease: A Mendelian Randomization StudySemantic proximity Read ↗

Effect of plasma vitamin C levels on Parkinson's disease and age at onset: a Mendelian randomization study.Semantic proximity Read ↗

Serum urate levels and neurodegenerative outcomes: a prospective cohort study and mendelian randomization analysis of the UK Biobank.Semantic proximity Read ↗

Mendelian randomization of serum urate and parkinson disease progression.Semantic proximity Read ↗

No clear support for a role for vitamin D in Parkinson's disease: A Mendelian randomization study.Semantic proximity Read ↗

Mendelian Randomization Analysis Reveals No Causal Relationship Between Plasma α-Synuclein and Parkinson's Disease.Semantic proximity Read ↗

Association of 25-hydroxyvitamin D with Parkinson's disease based on the results from the NHANES 2007 to 2018 and Mendelian randomization analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.