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Article

Genetic variations in methotrexate metabolic pathway genes influence methotrexate responses in rheumatoid arthritis patients in Malaysia.

Scientific reports - 13 Jul 2022

Sha Hong Xi, Veerapen Kumar, Chow Sook Khuan, Gun Suk Chyn, Lau Ing Soo, Lim Renee Lay Hong, Zulkifli Zaliha, Yow Yoon-Yen, Peh Suat Cheng, Hwang Jung Shan

Abstract excerpt

Methotrexate (MTX) is the most widely used disease-modifying anti-rheumatic drug (DMARD) for rheumatoid arthritis (RA). Many studies have attempted to understand the genetic risk factors that affect the therapeutic outcomes in RA patients treated with MTX. Unlike other studies that focus on the populations of Caucasians, Indian and east Asian countries, this study investigated the impacts of six single nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35831345
DOI: 10.1038/s41598-022-15991-0
PMCID: PMC9279481

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