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Article

Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate.

Pharmacogenomics - 1 Oct 2021

Sundbaum Johanna Karlsson, Baecklund Eva, Eriksson Niclas, Kohnke Hugo, Wallenberg Matilda, Cavalli Marco, Wadelius Claes, Wadelius Mia, Hallberg Pär

Abstract excerpt

Aim: To identify novel genetic variants predisposing to elevation of Alanine aminotransferase (ALT) in rheumatoid arthritis (RA) patients after initiation of methotrexate (MTX) treatment. Patients & methods: We performed genome-wide association studies in 198 RA patients starting MTX. Outcomes were maximum level of ALT and ALT >1.5-times the upper level of normal within the first 6 months of treatment....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 34521259
DOI: 10.2217/pgs-2021-0064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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