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Article

Polymorphisms and pharmacogenomics for the toxicity of methotrexate monotherapy in patients with rheumatoid arthritis: A systematic review and meta-analysis.

Medicine - 1 Mar 2017

Qiu Qi, Huang Jing, Lin Yang, Shu Xiaoming, Fan Huizheng, Tu Zhihua, Zhou Youwen, Xiao Cheng

Abstract excerpt

BACKGROUND: Methotrexate (MTX) is widely used and considered a first-line disease modifying antirheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA). However, 10% to 30% of patients discontinue therapy within a year of starting the treatment, usually because of undesirable side effects. Many of the relevant genes have been investigated to estimate the association between gene polymorphisms and...

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Identifiers

PMID: 28296761
DOI: 10.1097/MD.0000000000006337
PMCID: PMC5369916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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