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Article

Dopaminergic polymorphisms associated with medication responsiveness of gait in Parkinson's disease.

Parkinsonism & related disorders - 1 Mar 2018

Miller Nathaniel S, Chou Kelvin L, Bohnen Nicolaas I, Müller Martijn L T M, Seidler Rachael D

Abstract excerpt

BACKGROUND: Gait dysfunction is a common symptom of Parkinson's disease that can cause significant disability and put patients at risk for falls. These symptoms show variable responsiveness to dopaminergic therapy. OBJECTIVE: To determine whether dopaminergic (rs1076560 DRD2 G > T and rs4680 catechole-o-methyltranspherase (COMT) Val158Met) or brain derived neurotrophic factor (rs6265 BDNF Val66Met) genetic...

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Share to Gait Disorders, Neurologic
Share to DRD2 gene
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Share to Polymorphism, Single Nucleotide
Share to Receptors, Dopamine D2

Source

Open in PubMed Open full text

Identifiers

PMID: 29249680
DOI: 10.1016/j.parkreldis.2017.12.010
PMCID: PMC5826846

Genes

DRD2
BDNF
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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