Progression of gait dysfunction in incident Parkinson's disease: impact of medication and phenotype.

doi:10.1002/mds.26110

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Article

Progression of gait dysfunction in incident Parkinson's disease: impact of medication and phenotype.

Movement disorders : official journal of the Movement Disorder Society - 1 Mar 2015

Galna Brook, Lord Sue, Burn David J, Rochester Lynn

Abstract excerpt

Gait impairment in Parkinson's disease (PD) persists despite the use of dopaminergic therapy. Motor phenotype associated with greater postural instability and gait difficulty is related to a greater risk of motor decline and may be influenced by non-dopaminergic pathology. This study documents the progression of gait impairment over 18 months in an incident cohort of PD with regard to phenotype and medication....

Topics

Aged
Cognition Disorders
Cohort Studies
Disability Evaluation
Disease Progression
Dopamine Agents
Female
Gait Disorders, Neurologic
Humans
Incidence
Levodopa
Male
Middle Aged
Neuropsychological Tests
Parkinson Disease
Phenotype
Walking

Source

Open in PubMed

Identifiers

PMID: 25546558
DOI: 10.1002/mds.26110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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