Polymorphism of the dopamine transporter type 1 gene modifies the treatment response in Parkinson's disease.

doi:10.1093/brain/awv063

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Article

Polymorphism of the dopamine transporter type 1 gene modifies the treatment response in Parkinson's disease.

Brain : a journal of neurology - 1 May 2015

Moreau Caroline, Meguig Sayah, Corvol Jean-Christophe, Labreuche Julien, Vasseur Francis, Duhamel Alain, Delval Arnaud, Bardyn Thomas, Devedjian Jean-Christophe, Rouaix Nathalie, Petyt Gregory, Brefel-Courbon Christine, Ory-Magne Fabienne, Guehl Dominique, Eusebio Alexandre, Fraix Valérie, Saulnier Pierre-Jean, Lagha-Boukbiza Ouhaid, Durif Frank, Faighel Mirela, Giordana Caroline, Drapier Sophie, Maltête David, Tranchant Christine, Houeto Jean-Luc, Debû Bettina, Azulay Jean-Philippe, Tison François, Destée Alain, Vidailhet Marie, Rascol Olivier, Dujardin Kathy, Defebvre Luc, Bordet Régis, Sablonnière Bernard, Devos David

Abstract excerpt

After more than 50 years of treating Parkinson's disease with l-DOPA, there are still no guidelines on setting the optimal dose for a given patient. The dopamine transporter type 1, now known as solute carrier family 6 (neurotransmitter transporter), member 3 (SLC6A3) is the most powerful determinant of dopamine neurotransmission and might therefore influence the treatment response. We recently demonstrated that...

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Identifiers

PMID: 25805645
DOI: 10.1093/brain/awv063
PMCID: PMC5963414

Genes

COMT
DDC
MAOB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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