Article
Merkel Cell Carcinoma Patients Presenting Without a Primary Lesion Have Elevated Markers of Immunity, Higher Tumor Mutation Burden, and Improved Survival.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2018
Vandeven Natalie, Lewis Christopher W, Makarov Vladimir, Riaz Nadeem, Paulson Kelly G, Hippe Daniel, Bestick Amy, Doumani Ryan, Marx Tessa, Takagishi Seesha, Chan Timothy A, Choi Jaehyuk, Nghiem Paul
Abstract excerpt
Purpose: Patients presenting with nodal Merkel cell carcinoma without an identifiable (unknown) primary lesion (MCC-UP) are nearly twice as likely to survive compared with similarly staged patients with known primary lesions (MCC-KP). The basis of this previously reported finding is unclear.Experimental Design: Survival analyses and markers of immunity were evaluated in 123 patients with advanced MCC. Whole-exome...
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