Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PIP2 epigenetically represses rRNA genes transcription interacting with PHF8.

Biochimica et biophysica acta. Molecular and cell biology of lipids - 1 Mar 2018

Ulicna Livia, Kalendova Alzbeta, Kalasova Ilona, Vacik Tomas, Hozák Pavel

Abstract excerpt

Phosphoinositides are present in the plasma membrane, cytoplasm and inside the cell nucleus. Here we identify phosphatidylinositol-4,5-bisphosphate (PIP2) as a regulator of rRNA genes transcription at the epigenetic level. We show that PIP2 directly interacts with histone lysine demethylase PHF8 (PHD finger protein 8) and represses demethylation of H3K9me2 through this interaction. We identify the C-terminal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenesis, Genetic
Share to Genes, rRNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to HeLa Cells

Share to Histone Demethylases

Share to Phosphatidylinositol 4,5-Diphosphate

Share to RNA, Ribosomal

Share to Transcription, Genetic

Source

Identifiers

PMID: 29246768
DOI: 10.1016/j.bbalip.2017.12.008

Genes

PHF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PIP2 epigenetically represses rRNA genes transcription interacting with PHF8.PMID 29246768Read ↗

The RNA-dependent interactions of phosphatidylinositol 4,5-bisphosphate with intrinsically disordered proteins contribute to nuclear compartmentalizationSemantic proximity Read ↗

The sub-nucleolar localization of PHF6 defines its role in rDNA transcription and early processing events.Semantic proximity Read ↗

Control of Ribosomal RNA Synthesis by Hematopoietic Transcription FactorsSemantic proximity Read ↗

The basal transcription complex component TAF3 transduces changes in nuclear phosphoinositides into transcriptional output.Semantic proximity Read ↗

EZH2 promotes DNA replication by stabilizing interaction of POLδ and PCNA via methylation-mediated PCNA trimerizationSemantic proximity Read ↗

IGS38, a lncRNA from the human rDNA intergenic spacer, regulates rRNA transcription by altering rDNA chromatin organisation and activating the transcription machinerySemantic proximity Read ↗

Regulation of chromatin remodeling by inositol polyphosphates.Semantic proximity Read ↗

Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4.Semantic proximity Read ↗

Protein UFMylation regulates early events of ribosomal DNA double-stranded break responseSemantic proximity Read ↗

Fibrillarin Ribonuclease Activity is Dependent on the GAR Domain and Modulated by Phospholipids.Semantic proximity Read ↗

Human tumor suppressor p14ARF negatively regulates rRNA transcription and inhibits UBF1 transcription factor phosphorylationSemantic proximity Read ↗

Transcription factor regulation of ribosomal RNA in hematopoiesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.