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Article

Fibrillarin Ribonuclease Activity is Dependent on the GAR Domain and Modulated by Phospholipids.

Cells - 6 May 2020

Guillen-Chable Francisco, Corona Ulises Rodríguez, Pereira-Santana Alejandro, Bayona Andrea, Rodríguez-Zapata Luis Carlos, Aquino Cecilia, Šebestová Lenka, Vitale Nicolas, Hozak Pavel, Castano Enrique

Abstract excerpt

Fibrillarin is a highly conserved nucleolar methyltransferase responsible for ribosomal RNA methylation across evolution from Archaea to humans. It has been reported that fibrillarin is involved in the methylation of histone H2A in nucleoli and other processes, including viral progression, cellular stress, nuclear shape, and cell cycle progression. We show that fibrillarin has an additional activity as a...

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Identifiers

PMID: 32384686
DOI: 10.3390/cells9051143
PMCID: PMC7290794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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