Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Simvastatin intolerance genetic determinants: some features in ethnic Uzbek patients with coronary artery disease

5 Oct 2017

Abstract excerpt

Introduction: The objective is to study the influence of CYP3A5 (6986A>G), CYP2C9 (430C>T), CYP2C9 (1075A>C), SLCO1B1 (521T>C) and BCRP (ABCG2, 421C>A) gene polymorphisms on the development of simvastatin intolerance in ethnic Uzbek patients with coronary artery disease (CAD). Material and methods: The case group contained 50 patients with clinical simvastatin-induced intolerance symptoms; the control group...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to Lipoproteins and Cardiovascular Health
Share to Pharmacogenetics and Drug Metabolism

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29242847
DOI: 10.5114/amsad.2017.70597

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Simvastatin intolerance genetic determinants: some features in ethnic Uzbek patients with coronary artery diseasePMID 29242847Read ↗

Real-world pharmacogenetics of statin intolerance: effects of SLCO1B1, ABCG2, and CYP2C9 variantsSemantic proximity Read ↗

Genetic polymorphisms in ABCB1 are correlated with the increased risk of atorvastatin-induced muscle side effects: a cross-sectional study.Semantic proximity Read ↗

[Statin-induced adverse effects -- facts and genes].Semantic proximity Read ↗

A gene risk score using missense variants in SLCO1B1 is associated with earlier onset statin intolerance.Semantic proximity Read ↗

Genetic variation in statin intolerance and a possible protective role for UGT1A1.Semantic proximity Read ↗

Impact of SLCO1B1 and ABCB1 variants on statin efficacy and toxicity in a Tunisian population.Semantic proximity Read ↗

Prevalence of SLCO1B1 single nucleotide variations and their association with hypercholesterolaemia in hypercholesterolemic patients in Gauteng, South Africa.Semantic proximity Read ↗

Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with type 2 diabetes: a go-DARTS study.Semantic proximity Read ↗

Intolerance to statins: mechanisms and management.Semantic proximity Read ↗

Electronic health record (EHR)-detectable statin intolerance phenotypes: Prevalence and validation in real-world general practiceSemantic proximity Read ↗

Simvastatin-induced myopathy with concomitant use of cyclosporine: case report.Semantic proximity Read ↗

SLCO1B1 521T > C polymorphism associated with rosuvastatin-induced myotoxicity in Chinese coronary artery disease patients: a nested case-control study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.