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Article

Genetic variation in statin intolerance and a possible protective role for UGT1A1.

Pharmacogenomics - 1 Jan 2018

V Willrich Maria Alice, Kaleta Erin J, Bryant Sandra C, Spears Grant M, Train Laura J, Peterson Sandra E, Lennon Vanda A, Kopecky Stephen L, Baudhuin Linnea M

Abstract excerpt

The etiology of statin intolerance is hypothesized to be due to genetic variants that impact statin disposition and clearance. We sought to determine whether genetic variants were associated to statin intolerance. The studied cohort consisted of hyperlipidemic participants (n = 90) clinically diagnosed with statin intolerance by a cardiologist and matched controls without statin intolerance. Creatine kinase...

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Source

Identifiers

PMID: 29210320
DOI: 10.2217/pgs-2017-0146

Genes

ABCB1
ABCG2
GATM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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