Murine stroma adopts a human-like metabolic phenotype in the PDX model of colorectal cancer and liver metastases.

doi:10.1038/s41388-017-0018-x

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Article

Murine stroma adopts a human-like metabolic phenotype in the PDX model of colorectal cancer and liver metastases.

Oncogene - 1 Mar 2018

Blomme Arnaud, Van Simaeys Gaetan, Doumont Gilles, Costanza Brunella, Bellier Justine, Otaka Yukihiro, Sherer Félicie, Lovinfosse Pierre, Boutry Sébastien, Palacios Ana Perez, De Pauw Edwin, Hirano Touko, Yokobori Takehiko, Hustinx Roland, Bellahcène Akeila, Delvenne Philippe, Detry Olivier, Goldman Serge, Nishiyama Masahiko, Castronovo Vincent, Turtoi Andrei

Abstract excerpt

Cancer research is increasingly dependent of patient-derived xenograft model (PDX). However, a major point of concern regarding the PDX model remains the replacement of the human stroma with murine counterpart. In the present work we aimed at clarifying the significance of the human-to-murine stromal replacement for the fidelity of colorectal cancer (CRC) and liver metastasis (CRC-LM) PDX model. We have conducted...

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PMID: 29242606
DOI: 10.1038/s41388-017-0018-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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