Article
Genomic comparison of Lewis and Wistar-Furth rat substrains by use of microsatellite markers.
Journal of the American Association for Laboratory Animal Science : JAALAS - 1 Mar 2007
Callicott Ralph J, Ballard Scott T, Womack James E
Abstract excerpt
Inbred strains of the laboratory rat (Rattus norvegicus) are commonly used models in biomedical and behavioral research. Genetic contamination caused by breeding errors, incomplete inbreeding with residual allogenicity, mutation, and genetic drift all are known to contribute to substrain divergence. Therefore, colonies of inbred strains from various suppliers likely contain differing amounts of genetic variation....
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