Article

Macrophage efferocytosis is controlled by epigenetic modifications mediated by RBPJ

2025-10-12

Abstract excerpt

Efferocytosis, phagocytic clearance of apoptotic cells, is crucial for inflammation resolution and maintenance of tissue homeostasis. However, it is not known how epigenetic alterations govern macrophage-mediated efferocytosis. A Cleavage Under Targets and Release Using Nuclease (CUT&RUN) sequencing revealed a genome-wide selective suppression of H3K9me3, a heterochromatin mark that represses gene activity, in mac...

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Literature Corpus work: 147a8512-42df-5c82-a863-6d34ff9c8da3
DOI: 10.1101/2025.10.10.681723

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