Article
Primary Patient-Derived Cancer Cells and Their Potential for Personalized Cancer Patient Care.
Cell reports - 12 Dec 2017
Kodack David P, Farago Anna F, Dastur Anahita, Held Matthew A, Dardaei Leila, Friboulet Luc, von Flotow Friedrich, Damon Leah J, Lee Dana, Parks Melissa, Dicecca Richard, Greenberg Max, Kattermann Krystina E, Riley Amanda K, Fintelmann Florian J, Rizzo Coleen, Piotrowska Zofia, Shaw Alice T, Gainor Justin F, Sequist Lecia V, Niederst Matthew J, Engelman Jeffrey A, Benes Cyril H
Abstract excerpt
Personalized cancer therapy is based on a patient's tumor lineage, histopathology, expression analyses, and/or tumor DNA or RNA analysis. Here, we aim to develop an in vitro functional assay of a patient's living cancer cells that could complement these approaches. We present methods for developing cell cultures from tumor biopsies and identify the types of samples and culture conditions associated with higher...
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