Article
3-Dimensional Patient-Derived Lung Cancer Assays Reveal Resistance to Standards-of-Care Promoted by Stromal Cells but Sensitivity to Histone Deacetylase Inhibitors.
Molecular cancer therapeutics - 1 Apr 2016
Onion David, Argent Richard H, Reece-Smith Alexander M, Craze Madeleine L, Pineda Robert G, Clarke Philip A, Ratan Hari L, Parsons Simon L, Lobo Dileep N, Duffy John P, Atherton John C, McKenzie Andrew J, Kumari Rajendra, King Peter, Hall Brett M, Grabowska Anna M
Abstract excerpt
There is a growing recognition that current preclinical models do not reflect the tumor microenvironment in cellular, biological, and biophysical content and this may have a profound effect on drug efficacy testing, especially in the era of molecular-targeted agents. Here, we describe a method to directly embed low-passage patient tumor-derived tissue into basement membrane extract, ensuring a low proportion of...
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