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Article

Sociodemographic, clinical, and genetic factors associated with self-reported antidepressant response outcomes in the UK Biobank.

Psychological medicine - 12 Mar 2025

Kamp Michelle, Lo Chris Wai Hang, Kokkinidis Grigorios, Chauhan Mimansa, Gillett Alexandra C, McIntosh Andrew M, Pain Oliver, Lewis Cathryn M

Abstract excerpt

BACKGROUND: In major depressive disorder (MDD), only ~35% achieve remission after first-line antidepressant therapy. Using UK Biobank data, we identify sociodemographic, clinical, and genetic predictors of antidepressant response through self-reported outcomes, aiming to inform personalized treatment strategies. METHODS: In UK Biobank Mental Health Questionnaire 2, participants with MDD reported whether specific...

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Identifiers

PMID: 40071563
DOI: 10.1017/S0033291725000388
PMCID: PMC12080641

Genes

CYP2C19

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