Article
A FTH1 gene:pseudogene:microRNA network regulates tumorigenesis in prostate cancer.
Nucleic acids research - 28 Feb 2018
Chan Jia Jia, Kwok Zhi Hao, Chew Xiao Hong, Zhang Bin, Liu Chao, Soong Tuck Wah, Yang Henry, Tay Yvonne
Abstract excerpt
Non-coding RNAs play a vital role in diverse cellular processes. Pseudogenes, which are non-coding homologs of protein-coding genes, were once considered non-functional evolutional relics. However, recent studies have shown that pseudogene transcripts can regulate their parental transcripts by sequestering shared microRNAs (miRNAs), thus acting as competing endogenous RNAs (ceRNAs). In this study, we utilize an...
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