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Gene expression analysis delineates the potential roles of multiple interferons in systemic lupus erythematosus

23 Apr 2019

Abstract excerpt

A role for interferon (IFN) in systemic lupus erythematosus (SLE) pathogenesis is inferred from the prominent IFN gene signature (IGS), but the major IFN species and its relationship to disease activity are unknown. A bioinformatic approach employing individual IFN species gene signatures to interrogate SLE microarray datasets demonstrates a putative role for numerous IFN species, with prominent expression of...

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PMID: 31044165
DOI: 10.1038/s42003-019-0382-x

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