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Genetically unmatched human iPSC and ESC exhibit equivalent gene expression and neuronal differentiation potential

7 Dec 2017

Abstract excerpt

The potential uniformity between differentiation and therapeutic potential of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) remains debatable. We studied the gene expression profiles, pathways analysis and the ability to differentiated into neural progenitor cells (NPCs) and motor neurons (MNs) of genetically unmatched integration-free hiPSC versus hESC to highlight possible...

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PMID: 29235536
DOI: 10.1038/s41598-017-17882-1

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