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Article

Detection of heterogeneous resistance mechanisms to tyrosine kinase inhibitors from cell-free DNA.

Cell genomics - 10 Dec 2025

Parsons Heather A, Messer Conor, Santos Katheryn, Weiss Jakob, Merrell David, Danysh Brian P, Hughes Melissa E, Kirkner Gregory J, Patel Ashka, Hess Julian, Sendrick Kerry, Stewart Chip, Grant Elizabeth, Schlueter-Kuck Kristy, Grinshpun Albert, Wagle Nikhil, Veeraraghavan Jamunarani, Leone Jose Pablo, Freedman Rachel A, Metzger Otto, Schiff Rachel, Winer Eric P, Tolaney Sara M, Rimawi Mothaffar, Krop Ian E, Getz Gad, Lin Nancy U

Abstract excerpt

Though there has been substantial progress in the development of anti-human epidermal growth factor receptor 2 (HER2) therapies to treat HER2-positive metastatic breast cancer (MBC) within the past two decades, most patients still experience disease progression and cancer-related death. HER2-directed tyrosine kinase inhibitors can be highly effective therapies for patients with HER2-positive MBC; however, an...

Read the complete abstract on PubMed

Topics

Humans
Drug Resistance, Neoplasm
Female
Protein Kinase Inhibitors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Breast Neoplasms

Cell-Free Nucleic Acids

Erb-b2 Receptor Tyrosine Kinases

Mutation

Class I Phosphatidylinositol 3-Kinases

Exome Sequencing

Receptor, Fibroblast Growth Factor, Type 2

Middle Aged

Estrogen Receptor alpha

Tyrosine Kinase Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 40930104
DOI: 10.1016/j.xgen.2025.100987
PMCID: PMC12802574

Genes

ERBB2
ESR1
FGFR2
FGFR4
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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