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Article

IFN-gamma mediates the rejection of haematopoietic stem cells in IFN-gammaR1-deficient hosts.

PLoS medicine - 29 Jan 2008

Rottman Martin, Soudais Claire, Vogt Guillaume, Renia Laurent, Emile Jean-François, Decaluwe Hélène, Gaillard Jean-Louis, Casanova Jean-Laurent

Abstract excerpt

BACKGROUND: Interferon-gamma receptor 1 (IFN-gammaR1) deficiency is a life-threatening inherited disorder, conferring predisposition to mycobacterial diseases. Haematopoietic stem cell transplantation (HSCT) is the only curative treatment available, but is hampered by a very high rate of graft rejection, even with intra-familial HLA-identical transplants. This high rejection rate is not seen in any other...

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Identifiers

PMID: 18232731
DOI: 10.1371/journal.pmed.0050026
PMCID: PMC2214797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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