Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Lentiviral Gene Therapy Restores the Cellular Phenotype of Autosomal Recessive Complete IFN-γR1 Deficiency

11 Apr 2020

Abstract excerpt

Autosomal recessive (AR) complete interferon-γ receptor 1 (IFN-γR1) deficiency, also known as one genetic etiology of Mendelian susceptibility to mycobacterial disease (MSMD), is a life-threatening congenital disease leading to premature death. Affected patients present a pathognomonic predisposition to recurrent and severe infections with environmental mycobacteria or the Mycobacterium bovis bacillus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Immunodeficiency and Autoimmune Disorders
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32355867
DOI: 10.1016/j.omtm.2020.04.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Lentiviral Gene Therapy Restores the Cellular Phenotype of Autosomal Recessive Complete IFN-γR1 DeficiencyPMID 32355867Read ↗

Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infectionsSemantic proximity Read ↗

Recombinant IFN-γ1b Treatment in a Patient with Inherited IFN-γ Deficiency.Semantic proximity Read ↗

Human host genetic factors in nontuberculous mycobacterial infection: lessons from single gene disorders affecting innate and adaptive immunity and lessons from molecular defects in interferon-gamma-dependent signaling.Semantic proximity Read ↗

Diagnostic and therapeutic challenges in a child with complete Interferon‐γ Receptor 1 deficiencySemantic proximity Read ↗

A novel form of cell type-specific partial IFN-gammaR1 deficiency caused by a germ line mutation of the IFNGR1 initiation codon.Semantic proximity Read ↗

Haploinsufficiency at the human IFNGR2 locus contributes to mycobacterial disease.Semantic proximity Read ↗

Human complete Stat-1 deficiency is associated with defective type I and II IFN responses in vitro but immunity to some low virulence viruses in vivo.Semantic proximity Read ↗

Partial interferon-gamma receptor signaling chain deficiency in a patient with bacille Calmette-Guérin and Mycobacterium abscessus infection.Semantic proximity Read ↗

Clinical features of dominant and recessive interferon gamma receptor 1 deficiencies.Semantic proximity Read ↗

Viral infections in humans and mice with genetic deficiencies of the type I IFN response pathway.Semantic proximity Read ↗

Human interferon-gamma-mediated immunity is a genetically controlled continuous trait that determines the outcome of mycobacterial invasion.Semantic proximity Read ↗

Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteriaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.