Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer.

doi:10.1158/1055-9965.EPI-06-0767

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Article

Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2007

Cunningham Julie M, Hebbring Scott J, McDonnell Shannon K, Cicek Mine S, Christensen G Bryce, Wang Liang, Jacobsen Steven J, Cerhan James R, Blute Michael L, Schaid Daniel J, Thibodeau Stephen N

Abstract excerpt

Previous studies suggest that enzymes involved in the androgen metabolic pathway are susceptibility factors for prostate cancer. Estrogen metabolites functioning as genotoxins have also been proposed as risk factors. In this study, we systematically tested the hypothesis that common genetic variations for those enzymes involved in the androgen and estrogen metabolic pathways increase risk for sporadic and...

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Identifiers

PMID: 17507624
DOI: 10.1158/1055-9965.EPI-06-0767

Genes

GSTT1
NQO1
ESR1
SHBG
COMT
ESR2
GSTM1
GSTP1
KLK3
LHB
PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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