Article
Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains.
Structure (London, England : 1993) - 5 Mar 2013
Forst Alexandra H, Karlberg Tobias, Herzog Nicolas, Thorsell Ann-Gerd, Gross Annika, Feijs Karla L H, Verheugd Patricia, Kursula Petri, Nijmeijer Bianca, Kremmer Elisabeth, Kleine Henning, Ladurner Andreas G, Schüler Herwig, Lüscher Bernhard
Abstract excerpt
ADP-ribosyltransferases (ARTs) catalyze the transfer of ADP-ribose from NAD(+) onto substrates. Some ARTs generate in an iterative process ADP-ribose polymers that serve as adaptors for distinct protein domains. Other ARTs, exemplified by ARTD10, function as mono-ADP-ribosyltransferases, but it has been unclear whether this modification occurs in cells and how it is read. We observed that ARTD10 colocalized with...
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