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Article

Abnormal Rab11-Rab8-vesicles cluster in enterocytes of patients with microvillus inclusion disease.

Traffic (Copenhagen, Denmark) - 1 Jul 2017

Vogel Georg F, Janecke Andreas R, Krainer Iris M, Gutleben Karin, Witting Barbara, Mitton Sally G, Mansour Sahar, Ballauff Antje, Roland Joseph T, Engevik Amy C, Cutz Ernest, Müller Thomas, Goldenring James R, Huber Lukas A, Hess Michael W

Abstract excerpt

Microvillus inclusion disease (MVID) is a congenital enteropathy characterized by accumulation of vesiculo-tubular endomembranes in the subapical cytoplasm of enterocytes, historically termed "secretory granules." However, neither their identity nor pathophysiological significance is well defined. Using immunoelectron microscopy and tomography, we studied biopsies from MVID patients (3× Myosin 5b mutations and 1×...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28407399
DOI: 10.1111/tra.12486
PMCID: PMC5693299

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Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease.Semantic proximity Read ↗

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