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Article

Frequently used bioinformatics tools overestimate the damaging effect of allelic variants.

Genes and immunity - 1 Jan 2019

Andersen Line Lykke, Terczyńska-Dyla Ewa, Mørk Nanna, Scavenius Carsten, Enghild Jan J, Höning Klara, Hornung Veit, Christiansen Mette, Mogensen Trine H, Hartmann Rune

Abstract excerpt

We selected two sets of naturally occurring human missense allelic variants within innate immune genes. The first set represented eleven non-synonymous variants in six different genes involved in interferon (IFN) induction, present in a cohort of patients suffering from herpes simplex encephalitis (HSE) and the second set represented sixteen allelic variants of the IFNLR1 gene. We recreated the variants in vitro...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29217828
DOI: 10.1038/s41435-017-0002-z

Genes

IFNLR1
MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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