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Article

Silencing of miR-193a-5p increases the chemosensitivity of prostate cancer cells to docetaxel

1 Dec 2017

Abstract excerpt

BACKGROUND: Docetaxel-based chemotherapy failure in advanced prostate carcinoma has partly been attributed to the resistance of prostate cancer (PC) cells to docetaxel-induced apoptosis. Hence, there is an urgent need to identify mechanisms of docetaxel chemoresistance and to develop new combination therapies. METHODS: miR-193a-5p level was evaluated by qPCR in prostate tissues and cell lines, and its expression...

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Share to Cardiovascular, Neuropeptides, and Oxidative Stress Research
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PMID: 29216925
DOI: 10.1186/s13046-017-0649-3

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