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Identification of Docetaxel Resistance Genes in Castration-Resistant Prostate Cancer

25 Oct 2011

Abstract excerpt

Docetaxel-based chemotherapy is the standard first-line therapy in metastatic castration-resistant prostate cancer (CRPC). However, most patients eventually develop resistance to this treatment. In this study, we aimed to identify key molecular genes and networks associated with docetaxel resistance in two models of docetaxel-resistant CRPC cell lines and to test for the most differentially expressed genes in...

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PMID: 22027694
DOI: 10.1158/1535-7163.mct-11-0289

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