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Article

HMGB1-mediated autophagy promotes docetaxel resistance in human lung adenocarcinoma

5 Jul 2014

Abstract excerpt

BACKGROUND: Docetaxel resistance remains a major obstacle in the treatment of non-small cell lung cancer (NSCLC). High-mobility group box 1 (HMGB1) has been shown to promote autophagy protection in response to antitumor therapy, but the exact molecular mechanism underlying HMGB1-mediated autophagy has not been clearly defined. METHODS: Lung adenocarcinoma (LAD) cells were transfected with pcDNA3.1-HMGB1 or HMGB1...

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PMID: 24996221
DOI: 10.1186/1476-4598-13-165

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