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Mitochondrial DNA mutations in ageing and disease: implications for HIV?

Antiviral therapy - 1 Jan 2015

Payne Brendan A I, Gardner Kristian, Chinnery Patrick F

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations cause neurological and multisystem disease. Somatic (acquired) mtDNA mutations are also associated with degenerative diseases and with normal human ageing. It is well established that certain nucleoside reverse transcriptase inhibitor (NRTI) antiretroviral drugs cause inhibition of the mtDNA polymerase, pol γ, leading to a reduction in mtDNA content (depletion). Given this...

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PMID: 25032944
DOI: 10.3851/IMP2824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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