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Article

Dysregulated aldosterone secretion in persons of African descent with endothelin-1 gene variants.

JCI insight - 7 Dec 2017

Tan Jia W, Gupta Tina, Manosroi Worapaka, Yao Tham M, Hopkins Paul N, Williams Jonathan S, Adler Gail K, Romero Jose R, Williams Gordon H

Abstract excerpt

Compared with persons of European descent (ED), persons of African descent (AD) have lower aldosterone (ALDO) levels, with the assumption being that the increased cardiovascular disease (CVD) risk associated with AD is not related to ALDO. However, the appropriateness of the ALDO levels for the volume status in AD is unclear. We hypothesized that, even though ALDO levels are lower in AD, they are inappropriately...

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Identifiers

PMID: 29212952
DOI: 10.1172/jci.insight.95992
PMCID: PMC5752283

Genes

EDN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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