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Article

Mineralocorticoid Receptor and Aldosterone: Interaction Between NR3C2 Genetic Variants, Sex, and Age in a Mixed Cohort.

The Journal of clinical endocrinology and metabolism - 18 Dec 2024

Heydarpour Mahyar, Parksook Wasita W, Pojoga Luminita H, Williams Gordon H, Williams Jonathan S

Abstract excerpt

CONTEXT: Hypertension, a prevalent cardiovascular risk, often involves dysregulated aldosterone and its interaction with the mineralocorticoid receptor (MR). Experimental designs in animal models and human cohorts have demonstrated a sex and age dependency of aldosterone secretion that expands our pathophysiologic understanding. OBJECTIVE: This study explores the genetic variation of NR3C2, which encodes MR, in...

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Source

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Identifiers

PMID: 38437868
DOI: 10.1210/clinem/dgae127
PMCID: PMC11651684

Genes

NR3C2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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